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    "name": "onekgpd",
    "summary_en": "Query the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. Use when a question is about individuals or variants in the 1000 Genomes Project cohort: which individuals carry variants matching specific criteria in a gene or region, which individuals are homozygous-reference at a position, which variants exist in the dataset or carried by specified individuals in a gene or region, the relatedness between two specified individuals. Variants are returned with 1000 Genomes allele frequencies (AF), gnomAD v4.1 exome and genome AF, AlphaMissense score, and HGVSp annotations.",
    "summary_zh": "查询1000 Genomes Project数据集（3,202个全基因组测序个体，GRCh38）在个体参与者层面的信息。当问题涉及1000 Genomes Project队列中的个体或变异时使用：哪些个体携带符合特定条件的基因或区域变异，哪些个体在某个位置为纯合参考，数据集中或指定个体在基因或区域中存在哪些变异，两个指定个体之间的亲缘关系。返回的变异附带1000 Genomes等位基因频率（AF）、gnomAD v4.1外显子组和基因组AF、AlphaMissense评分和HGVSp注释。",
    "description_en": "This skill queries the 1000 Genomes Project dataset (3,202 whole-genome-sequenced individuals, GRCh38) at the level of individual participants. It supports finding variants carried in a region (cohort-wide or within specified individuals), finding which individuals carry variants matching criteria, identifying homozygous-reference individuals at a position, and determining relatedness between two individuals. Variant results include 1000 Genomes allele frequencies, gnomAD v4.1 exome and genome AF, AlphaMissense score, and HGVSp annotations. The skill requires Python >=3.11 and uses uv to run scripts. Variant and sample queries require outbound network access to a public 1000 Genomes query endpoint over TLS; sample/population metadata commands run offline using bundled data. No credentials or API keys are required. The skill is distributed under the MIT license.",
    "description_zh": "该技能用于查询1000 Genomes Project数据集（3,202个全基因组测序个体，GRCh38）在个体参与者层面的信息。支持查找区域内携带的变异（全队列或指定个体内）、查找携带符合条件变异的个体、识别某位置纯合参考的个体，以及确定两个个体间的亲缘关系。变异结果包含1000 Genomes等位基因频率、gnomAD v4.1外显子组和基因组AF、AlphaMissense评分和HGVSp注释。该技能需要Python >=3.11，并使用uv运行脚本。变异和样本查询需要通过TLS对公共1000 Genomes查询端点进行出站网络访问；样本/群体元数据命令使用捆绑数据完全离线运行。无需凭据或API密钥。该技能以MIT许可证分发。",
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          "Getting dataset totals and population metadata"
        ],
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